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Home / HRT / Evorel


  • Pack of 8 Evorel 25 estradiol transdermal patches
  • Box of Evorel 25 with a sachet
  • Sachet of Evorel transdermal patch

COVID-19 update: Our services are running as normal.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

How to buy Evorel?

Evorel can be obtained by any woman experiencing the menopause who has completed a consultation with a medical professional. Once you have had an initial face-to-face consultation and have been safely prescribed Evorel, you can reorder online if you wish. This includes a short online consultation.

Is it safe to order online?

When ordering from a certified online pharmacy, you can be ensured that your medication is safe. If the pharmacy doesn't ask you to complete essential health and medical question, however, this is a telltale sign that the website isn't certified. The website should also display clear signs that it is registered and approved by the relevant authorities. In the UK, this includes being registered by the MHRA, GMC .

All medication will be delivered in tamper proof packaging complete with the full patient leaflet, which confirms that the medication is clinically proven and highly effective.

What is included in the price?

When ordering Evorel online here at Medilico, this is an all-inclusive price including the prescription, consultation, medication and delivery. There are no hidden costs. The price adjusts depending on the dosage and quantity you have ordered.

Can you buy without a prescription?

Hormone replacement therapy is a prescription-only treatment. It's not possible to buy it over-the-counter for safety reasons. To order Evorel online you will first need a prescription from your doctor. This is because you may need a physical examination and a full medical history check-up. Once you have been issued a prescription you can buy Evorel patches online after a quick online consultation.

What Is Evorel?

Evorel is a patch that replaces the hormones lost during your menopause. Evorel is a good alternative to women who dislike taking pills.

Menopause can be a difficult time for women who experience side effects such as hot flashes, night sweats and a dry vagina. Evorel supports women struggling to cope with these symptoms by replacing the hormones that their ovaries are no longer making.

Evorel uses a patch system of delivery, there are no tablets involved. If Evorel is suited to your needs it is available in three different doses.

  • Evorel - an oestrogen only patch available in 25, 50, 75 and 100mg doses, which is suited to women without a uterus
  • Evorel Conti - a combined HRT of oestrogen and progesterone available as a 50mg dose
  • Evorel Sequi - a combined HRT of Evorel 50mg and Evorel Conti

How Does Evorel Work?

Evorel works by replacing the hormones your body is no longer releasing.

Menopause is a natural condition, but it's not a simple process for all women. Whilst some experience no difficulties, other women can experience a decrease in their quality of life. Side effects of menopause, which are also experienced during the peri-menopause, include hot flashes, night sweats, insomnia, weight gain, dry vagina, painful sex, mood changes, dry skin or acne, dry brittle hair, very heavy periods, fatigue, anxiety and osteoporosis. Evorel reduces the severity of these symptoms.

Every woman is different which is why Evorel is available in different doses. If you're struggling to cope with menopause chat to your doctor about using HRT to counteract the symptoms of menopause. You will not need to take Evorel forever. HRT is a prop to help you through the period of changing hormones.

One of the risk factors during menopause is osteoporosis. Women's bones are strengthened by oestrogen. When menopause takes place your ovaries create fewer hormones including oestrogen. This means your bones can lose mass. In some individuals, this can lead to severe bone thinning and the development of osteoporosis. Osteoporosis is when your bones are fragile and break easily. The hormones in Evorel help to strengthen your bones and can prevent osteoporosis developing in individuals at risk.

How To Use Evorel

If you have tried natural ways to deal with your menopause such as improving your diet, drinking more water, exercising and getting more sleep but these have not helped, HRT is a clinically proven and effective option. Your doctor will have all the information you need and will help you make an informed choice.

Using Evorel is simple. You will be prescribed the lowest dose to suit your symptoms. If this dose does not minimise any side effects of the menopause there are higher doses available.

Evorel: Is for women without a uterus and should be changed twice a week. If you start on a Monday you will need to change the patch on a Thursday and then again on a Monday. Stickers are provided in the treatment box to help you remember.

Evorel Conti: Use Evorel Conti the same way as Evorel. It should be changed twice a week. If you start on a Monday you will need to change the patch on a Thursday and then again on a Monday. Stickers are provided in the treatment box to help you remember. Evorel Conti also contains progesterone to counteract any oestrogen released from your ovaries. Therefore it is suited to women who still have a uterus.

Evorel Sequi: Evorel Sequi patches need to be changed twice as week too but because Sequi is a mixture of Evorel 50 and Evorel Conti you must take them in the right order as follows:

Week 1 and 2 - use Evorel 50

Week 3 and 4 Use Evorel Conti

Do not leave a break between Evorel 50 and Conti patches. They should be changed on the Monday/Thursday pattern.

How To Apply Evorel Patches

How and where you choose to stick the patches is important. You should not use patches on the top half of your body. Many women choose a thigh or their bottom. Your skin should be hair-free and flat e.g. do not put your patch on a crease such as behind your knee. Your waistline is also unsuitable as clothing may rub the patch. You should never apply Evorel to your breasts.

Using moisturiser, talc or attaching your patch to hot, damp skin can interfere with hormone release and may cause the patch to fall off. Ensure your skin is cool, clean and dry, and that you apply a patch as soon as you open its protective foil pouch.

  • To apply Evorel correctly you should open the packet using the notches as a guide, then remove the patch and peel away the protective sticky layer. Do not touch the sticky side.
  • Apply the patch and press firmly over the entire surface area paying particular attention to the edges. Once it is in place you can peel away the remaining backing paper.

To Remove the Evorel Patch

To remove Evorel you should peel up one side and gently pull it away from your skin. Removing Evorel will not hurt. Fold Evorel in half so the sticky sides meet and put it in the household rubbish. You should not flush Evorel down the toilet for environmental reasons.

You may be left with a sticky residue which is easily washed away. When you apply your next patch do so in a different place to minimise the risk of skin irritation.

If you forget to change your patch you should change it as soon as you remember but keep to your original patch changeover days e.g. Monday and Thursday. If you don't change the patch until Tuesday you should still change it again on Thursday. You may experience some spotting and bleeding if you forget to change the patch.

Evorel Dosages

Evorel is available is different doses but you should always use the lowest dose to suit your symptoms. Excessive use of HRT can lead to side effects.

  • Evorel patches are available in a 25,50,75 and 100mg dose of the oestrogen estradiol.
  • Evorel Conti patches are available as a 50mg dose of the oestrogen estradiol hemihydrate and the progesterone norethisterone acetate.
  • Evorel Sequi contains Evorel in a 50mg dose and Evorel Conti patches in a 50mg dose of the oestrogen estradiol hemihydrates and the progesterone norethisterone acetate.

Evorel Side Effects

Unwanted side effects can occur with any prescription medication. They are one of the main reasons why medicines are not available to all. As well as the serious conditions mentioned in the precautions section, Evorel may cause side effects ranging from common to rare.

Serious side effects that are rare but require medical attention include, jaundice, migraines, increased blood pressure, long, heavy or irregular vaginal bleeding, a rash with blisters and peeling skin around the eyes, mouth and genitals or fits. Very rarely, women experience an allergic reaction to the ingredients in Evorel. If you experience shortness of breath, hives or a swollen, mouth, throat or lips seek immediate medical help.

A very common side effect is local irritation where the patch is applied. To reduce this effect try to vary where you place your patch.

Common side effects affecting less than one in ten women include:

  • Feeling nervous or depressed
  • Feeling emotions
  • Insomnia
  • Headaches
  • Nausea and stomach upsets
  • Pain in muscles joints and back
  • Breast tenderness
  • Painful periods
  • Water retention
  • Weight gain

More uncommon side effects that are experienced by less than one in 100 are feeling dizzy, lack of interest in sex, fungal infections such as thrush, palpitations, numb or tingling hands and feet, non-cancerous breast lumps, womb lining thickening and concentration problems.

Always read the enclosed leaflet with your Evorel for a full list of common and rare side effects.

Evorel Precautions

Although Evorel contains oestrogen and progesterone like the combined pill, the levels are not high enough to provide contraception. If you are still having periods or it's been a year since your last period you may still be fertile. Speak to your doctor about suitable contraception. It's not advised that you use hormonal contraception alongside HRT because it raises the amount of hormones in your blood and may cause unwanted side effects. Barrier methods such as condoms and caps or diaphragms with spermicide are options.

Evorel is not capable of preventing sexually transmitted infections; only condoms can prevent the spread of STIs because they prevent the exchange of body fluids. Your doctor or local sexual health clinic can arrange a screening for STIs if you believe you have developed one.

The use of hormones can slightly raise the risk of some conditions:

Blood Clots: The oestrogen in HRT can make blood more prone to sticking. In very few individuals this can lead to the formation of a blood clot. Symptoms include heat, swelling or pain in the local area or breathless and coughing if a blood clot forms in the lungs. If a blood clot breaks away from the artery it can cause a stroke or heart attack. The increased risk is very low, but you are at a higher risk if you are overweight, smoke, travel long distance by air or are immobile for a period of time e.g. you've had an operation.

Cancer: Use of oestrogen can raise the risk of breast and ovarian cancer. The risk is low but if you have a family history or have experienced breast or ovarian cancer yourself you may not be prescribed Evorel. The risk returns to normal a few years after you stop taking HRT. To protect yourself, always attend mammograms and regularly check your breasts. If you experience any vaginal bleeding that is unexplained, speak to your doctor.

Oestrogen only HRT such as Evorel 25, 50, 75 or 100mgs can cause thickening of the womb lining.

Women over the age of 60 using combined HRT raise their risk of heart disease and stroke very slightly and women over the age of 65 have a slightly higher risk of memory loss.

Other Evorel precautions involve medicines that may cause an interaction:

Who Can and Can't Use Evorel

Women who are not experiencing menopausal symptoms should not use HRT. Many menopausal women use Evorel successfully to reduce their symptoms but there are some women for whom it is not suited. You should not use Evorel if you have or have had:

  • Breast cancer
  • Womb lining cancer
  • Unexplained vaginal bleeding
  • A blood clot or a blood clotting disorder
  • If you recently had a blood clot associated illness such as a heart attack, stroke, angina
  • Liver disease
  • Porphyria
  • Untreated endometrial hyperplasia
  • An allergy to Evorel
  • If you are pregnant or are breastfeeding
  • Evorel 25, 50, 75 and 100 is designed for women who do not have their uterus

The following conditions may mean you can't use Evorel, but your doctor will decide if your risks outweigh the benefits. Some women struggle with menopause symptoms to the extent it prevents them living their life. If this is the case you may be prescribed Evorel but under special precautions and with extra monitoring.

You may be able to use Evorel if you have or have had:

  • An increased risk of blood clots for example you smoke or are overweight
  • A close relative with oestrogen sensitive cancer
  • High blood pressure
  • Liver disorder
  • Diabetes
  • Gallstones
  • Migraines
  • Lupus (SLE) or other autoimmune disease
  • Epilepsy
  • Asthma
  • Fibroids
  • Endometriosis
  • Endometrial hyperplasia
  • Disease affecting the eardrum
  • High levels of fat in your blood e.g cholesterol
  • Fluid retention

If you have any of these conditions you may be more suited to the lower doses of Evorel.

Other Medication Interactions

Hormones can affect how your medicines work. In some cases it reduces their efficiency or conversely the medicine may prevent Evorel from working. This includes:

  • Epilepsy medicines such as phenobarbital, phenytoin, carbamazepine and lamotrigine. Lamotrigine can stop Evorel from working too
  • Some antibiotics including rifampicin, rifabutin, nevirapine, efavirenz, ritonavir or nelfinavir
  • Some HIV medications
  • Medicine for high blood pressure in the lungs such as Bosentan
  • St John's Wort - a herbal remedy for depression

If you take any medicines, either prescribed or over-the-counter, ensure you inform your doctor, dentist or pharmacist. HRT may also affect laboratory tests so it's important to mention your HRT tablets if you need any medical tests.

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