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  • Pack of 84 Premique Low Dose 0.3mg/1.5mg modified-release tablets
  • Box of Premique conjugated estrogens and medroxyprogesterone acetate tablets with blister packs
  • Front and rear view of Premique 0.3mg/1.5mg tablet blister packs

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Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

How to buy Premique?

Premique is not available over-the-counter. To obtain it, or any other type of HRT, you will first need a prescription from your doctor. Once you have a prescription you can order Premique online from a safe, reputable online pharmacy. Ensure that you declare any changes in your health since your original doctor's prescription.

If you are experiencing the menopause and are finding it hard to cope with its changing symptoms, hormone replacement therapy is worth consideration. HRT has helped many women worldwide cope with the menopause. You will not need to take a pill forever - HRT is a temporary support that can vastly improve your quality of life as your body adjusts.

Is it safe to order online?

When ordering from a certified online pharmacy, you can be ensured that your medication is safe. If the pharmacy doesn't ask you to complete essential health and medical question, however, this is a telltale sign that the website isn't certified. The website should also display clear signs that it is registered and approved by the relevant authorities. In the UK, this includes being registered by the MHRA, GMC .

All medication will be delivered in tamper proof packaging complete with the full patient leaflet, which confirms that the medication is clinically proven and highly effective.

What is included in the price?

When ordering Azithromycin online here at Medilico, this is an all-inclusive price including the prescription, consultation, medication and delivery. There are no hidden costs. The price adjusts depending on the dosage and quantity you have ordered.

Can you buy without a prescription?

No. All clinically proven medication requires a valid prescription and Premique is no exception. This is to confirm the medication is perfectly safe and highly effective for you to use. The prescription process will involve a short consultation – this is the same in person as well as online – and involves medical and personal question to ensure Premique is compatible with you.

What is Premique?

Premique and Premique Low Dose are tablet forms of HRT. They contain two types of female sex hormones - naturally occurring conjugated oestrogens and a synthetic progesterone called medroxyprogesterone acetate. These hormones work together to alleviate menopause symptoms quickly and effectively.

Women who still have their wombs (have not had a hysterectomy) should take a combined HRT like Premique as their ovaries may still be producing oestrogen of their own. When this happens the extra oestrogen can cause a build up in the womb lining that may lead to complications such as endometrial cancer. Premique is a period-free HRT, meaning you won't experience monthly bleeds that come with other HRTs.

Premique is also used to prevent and treat the bone-thinning disease osteoporosis. Osteoporosis affects women experiencing their menopause as oestrogen is used to build strong bone mass. Without oestrogen, some women are at risk of bone thinning. This leads to easily fractured bones.

How does Premique work?

Women experience the menopause around the age of 44-55 but sometimes it can happen earlier, either naturally or due to a hysterectomy. As women age a number of eggs in the ovaries decrease and therefore the ovaries produce less oestrogen. This happens gradually beginning with 'peri-menopause' when symptoms are often at their worst. Menopause describes the total absence of periods. It can take years for a woman to reach full menopause.

During this time your levels of oestrogen will gradually drop. Some women do not experience many symptoms, but others experience many which can become overwhelming, distressing and impede everyday life. At this point, daily continuous HRT such as Premique can make a big difference. By increasing levels of oestrogen Premique can prevent the menopausal symptoms of:

  • Hot flushes - these are very common symptoms brought about by surges of hormones
  • Night sweats
  • Insomnia
  • A dry vagina
  • Skin tingling and irritation
  • Urinary tract infections
  • Low moods and lack of interest in sex
  • Osteoporosis
  • Depression due to psychological aspects

HRT should only be taken when all other options have not worked and then only for the shortest time possible. You will not need to take HRT forever, it simply supports you through a difficult time when oestrogen levels are decreasing and your hormones are unstable. All HRT users need regular check-ups with their doctor to assess if they still require HRT.

How To Use Premique

Premique and Premique low dose need to be taken every day. There are 28 pills in a pack that all contain the same amount of hormone. Your tablets should be taken at the same time each day to ensure an even spread of hormone replacement.

When you finish your current strip of HRT you should not take a break, but continue to the next strip. Some women attempt a seven-day break as they are used to taking a combined contraceptive pill that requires a monthly bleed, however, Premique does not require a break from tablets - you should take one every day.

Swallow each tablet with a drink. Do not crush or chew the tablet or try to dissolve it in water. The tablet needs to be whole so it is absorbed at the correct rate. You can take it with food if you find swallowing tablets difficult.

If you forget a dose, don't worry. Take it when you remember unless it is time for the next tablet. If so, discard the missed pill. Missed pills can result in a short vaginal bleed. This is nothing to worry about, but if you are concerned, speak to your doctor.

Don't double up on your Premique tablets as this increases the risk of side effects and does not double the effect of Premique.

How to start Premique

  • If you are not currently taking any HRT you can begin Premique straight away.
  • If you are currently taking another type of period-free HRT begin Premique when you wish.
  • If you are changing from an HRT that gives you a monthly bleed start Premique on the day following your current strip.
  • If you take too many Premique tablets, you may feel unwell with nausea, dizziness, and potentially a short vaginal bleed.
  • If you need an operation you may have to stop taking Premique 4-6 weeks in advance. Your doctor will advise you further.

Premique Dosages

Every woman is different Premique is available in two strengths:

  • Premique Low Dose tablets that contain 300 micrograms of conjugated oestrogen and 1.5 milligrammes of medroxyprogesterone
  • Premique tablets that contain 625 micrograms of conjugated oestrogen and 5 milligrammes of medroxyprogesterone.
  • Your doctor will aim to prescribe the lowest dose to treat your symptoms for as short a time as necessary. Speak to your doctor if you think your dose is too strong or is too weak.

Premique Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The more common and milder side effects may wear off over time. The benefits of HRT can be greater than the mild side effects so it is worth preserving if you are able. If the mild side effects do not pass or they worsen, see your doctor for advice.

Common side effects affecting more than 1 in 10 women; breast pain, breakthrough bleeding or spotting, period pain, breast tenderness and nipple discharge, depression, muscle, joint aches or leg cramps, an increase or decrease in weight and changes in your triglyceride levels.

Uncommon side effects affecting up to 1 in 100 women; changes in your periods, vaginal discharge, vaginal thrush, nausea, bloating and abdominal pain, a headache and migraine, dizziness, changes in mood including anxiety, changes in your interest in sex, visible swelling of the face or ankles, itchiness, acne, difficulty wearing contact lenses and gallbladder disease.

Rare side effects affecting up to 1 in 1,000 women; vomiting, changes in breast tissue, milky secretion from the breasts, irritability, the increase in hair growth, a worsening of asthma, increased size of fibroids, worsening of epilepsy, inflammation of veins just under the skin, inflammation of the pancreas and irregular dark spots. Very rare side effects include an allergic reaction characterised by swollen lips, throat and mouth or hives and body itching. If you experience an allergic reaction seek immediate medical advice.

Other rare side effects include jaundice, hypocalcaemia, blurred vision or loss of vision, the growth of benign liver tumours and an increase in blood pressure. Speak to your doctor if you notice any of these symptoms and ensure you undergo regular medical check-ups, at least once a year.

Premique Precautions

Premique is used by many women without any problems. It's a highly regarded form of combined HRT that can improve a woman's quality of life, however, it is not recommended for some individuals. Do not use Premique if:

  • You are allergic to conjugated oestrogens or medroxyprogesterone acetate
  • If you have ever had or currently have breast cancer
  • If you have cancer which is sensitive to oestrogens, such as cancer of the womb lining
  • If you have any unexplained vaginal bleeding
  • If you have excessive thickening of the womb lining that is not being treated.
  • If you have had or currently have a blood clot in a vein or your lungs
  • If you have a blood clotting disorder such as protein C, protein S, or antithrombin deficiency
  • If you've had or have had a heart attack, stroke or angina.
  • If you have or have ever had a liver disease and your liver function tests have not returned to normal.
  • If you have a rare blood problem called "porphyria" which is passed down in families
  • If you are pregnant or you are breastfeeding

All HRT is a prescription medicine and therefore not suitable for every woman. You should speak to your doctor if you have any of the following conditions as you may not be suitable for Premique, or you may need an altered dose and more frequent monitoring; fibroids inside your womb, the growth of womb lining outside your womb (endometriosis) or a history of excessive growth of the womb lining (endometrial hyperplasia), increased risk of developing blood clots, at increased risk of getting an estrogen-sensitive cancer, high blood pressure, heart disease, a liver disorder, diabetes, gallbladder disease or gallstones, a migraine or severe headaches, fluid retention due to cardiac or kidney problems, Lupus (SLE), epilepsy, asthma, otosclerosis, low blood calcium levels and a very high level of fat in your blood.

These precautions do not mean you are unsuitable for Premique, but that you may need extra support.

As well as the precautions listed above, there are some warnings associated with all combined HRT including Premique. These include increased risk of serious illness such as:

  • Stroke
  • The risk of having a stroke is raised in women using HRT by around 1.5 times. If you are older, have high blood pressure, smoke, or drink alcohol excessively the risk increases again.
  • Blood clots
  • Oestrogen can cause blood to become sticky and this leads to a raised risk of blood clots called thrombosis or DVT. The risk is 1.3 - 3 times higher than non-HRT users. If blood clots break loose they can travel to the heart, causing a heart attack, to the brain causing a stroke or to the lungs causing a pulmonary embolism. The risk is higher in the first year of taking HRT and if you travel long distance by air. Speak to your doctor about the risk of using HRT and flying long distance. You may be required to take extra precautions such as wearing medical stockings and performing exercises.
  • Breast Cancer
  • Do not use Premique if you have had, currently, have or are suspected of having breast cancer.
  • Evidence shows women taking HRT are more likely to develop breast cancer. The risk returns to normal after a few years of stopping the treatment. All women should perform regular breast examination and attend mammogram screenings.
  • Ovarian Cancer
  • Using HRT has been associated with a higher risk of ovarian cancer. It's difficult to diagnose ovarian cancer as the symptoms are not obvious. If you have any unexplained bleeding, abdominal pain or fatigue speak to your doctor.
  • Memory Loss
  • HRT is thought to cause an increased risk of memory loss if it's begun over the age of 65.

Other Medication Interactions

Premique has some interactions with other medicines. You should mention all your current medications to your doctor before you are prescribed HRT, and mention you take Premique to your doctor, dentist and pharmacist if you are required to take a short or long course of medicines.

In some cases, Premique interferes with the action of medicines, and conversely some medicines stop Premqiue working correctly. These medicines include:

  • Medicines for epilepsy such as phenobarbital, phenytoin, and carbamazepine
  • Medicines for tuberculosis such as the antibiotics rifampicin and rifabutin
  • Medicines for HIV infection such as nevirapine, efavirenz, ritonavir and nelfinavir
  • Herbal remedies containing St. John's wort
  • Metyrapone most commonly used in the treatment of Cushing's syndrome
  • Aminoglutethimide used in the treatment of breast cancer and Cushing's syndrome

Ensure your doctor knows you take HRT if you need any laboratory tests or if you need to attend the A&E department.

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