• Prempak C
  • Prempak C
  • Prempak C
  • Prempak C
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Prempak-C is an HRT treatment that is proven effective in minimising symptoms of the menopause such as hot flushes, night sweats and mood swings. This particular tablet can be taken for up to a year before review and can also be used in postmenopausal women, for early menopause, women who smoke, women who have osteoporosis and women with a thin body frame.

At a glance:

  • Available in tablet form
  • Easy to take with clearly labeled blister packs
  • Contains both oestrogen and progestrone
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Our pharmacy will send your treatment right to your doorstep. this service includes doctor prescription and 24h express delivery.

  • Free next day delivery
  • Prescription included
  • 3h 10min for delivery tomorrow
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How to buy Prempak-C?

When buying Prempak-C online, you will still require a prescription as it is clinically proven medication. This can be easily obtained when completing our quick online consultation. A certified doctor reviews this and then you can order Prempak-C online.

Is it safe to order online?

When ordering from a certified online pharmacy, you can be ensured that your medication is safe. If the pharmacy doesn't ask you to complete essential health and medical question, however, this is a telltale sign that the website isn't certified. The website should also display clear signs that it is registered and approved by the relevant authorities. In the UK, this includes being registered by the MHRA, GMC .

All medication will be delivered in tamper proof packaging complete with the full patient leaflet, which confirms that the medication is clinically proven and highly effective.

What is included in the price?

When ordering Prempak-C online here at HEALTHSITE, this is an all-inclusive price including the prescription, consultation, medication and delivery. There are no hidden costs. The price adjusts depending on the dosage and quantity you have ordered, which can be seen below:


Can you buy without a prescription?

All clinically proven medication in the UK requires a valid prescription. This includes Prempak-C, and all other HRT treatments, to confirm the medication is perfectly safe and highly effective for you to use. The prescription process will involve a short consultation – this is the same in person as well as online – and involves medical and personal questions to ensure Prempak-C is compatible with you.

What is Prempak-C?

Prempak-C is a relatively new hormonal replacement therapy that is available in two different concentrations, however, each blister pack is the same and contains two types of pills; one set of pills contains the conjugated oestrogens and the other type contains the progesterone, norgestrel.

What is Prempak-C used for?

Prempak-C is a type of hormonal replacement therapy (HRT) used for the relief of symptoms that occur during menopause. It is also used as a therapy for prevention of osteoporosis in postmenopausal women, who are at risk for fractures. These women are unable to take any other prescription medication to prevent bone thinning. It should be understood that the use of Prempak-C to prevent osteoporosis in postmenopausal women is a last option and should be used with caution.

Prempak-C is effective for use in postmenopausal women, who are at a high risk for developing fractures including those who smoke, have recently been on corticosteroid therapy, have a family history of osteoporosis, have a thin body frame, and have had early menopause. Oestrogen supplements have been shown to prevent bone thinning and fractures that often occur in postmenopausal women.

All women who take Prempak-C need to be followed closely by their healthcare provider as there is a small risk of breast cancer; your doctor will perform a thorough breast exam and may even recommend a mammogram. It is also important that you regularly examine your breast at home.

How does Prempak-C work?

During menopause there is a decline in the production of the female sex hormones by the ovaries. The decreasing levels of these sex hormones lead to symptoms like hot flushes, vaginal dryness, mood changes, night sweats or itching. Prempak-C substitutes for the natural oestrogen and progesterone in the body and helps alleviate the symptoms of menopause. These hormones also increase the thickness of the vaginal lining and increase mucus production, thereby providing relief from dryness and painful intercourse.

The benefit of a combination formulation like Prempak-C is because oestrogen alone can lead to cancer of the uterus. The progesterone found in Prempak-C balances out the actions of oestrogen and reduces the risk of uterine cancer.

How to take Prempak-C

HRT like Prempak-C should only be used for a short time. Most doctors prescribe Prempak-C for 6-12 months.

  • Prempak-C pills come in a blister calendar pack.
  • You take the tablets in the order arranged in the pack, starting on day one.
  • You will take the oestrogen pill everyday until day 16.
  • From day 17 onwards, you will take an oestrogen plus a norgestrel tablet till day 28.
  • You then start the next cycle without any break.
  • After 12 months of Prempak-C, all women must be examined by their healthcare provider to review if therapy should be continued.

The tablets can be taken with or without food. Try and take the pills at the same time every day this will make it easy to remember.

At the end of each cycle, you will have some type of withdrawal bleeding- this usually happens within three to six days after you take the norgestrel tablets.

What if I miss a dose?

If you forget to take one pill, you should take it as soon as you can remember. However, if you remember too close to the time of the next pill, then forget the missed dose and only take the pill that is scheduled. Never double up on the dose as this can lead to adverse effects. If you do miss a tablet, the frequency and intensity of the breakthrough bleeding will be more obvious for a few months.

Prempak-C Side Effects

Some women may develop side effects from Prempak-C. These side effects do not occur in all women and are generally seen when you first start Prempak-C. The majority of these side effects subside within a few months. If they do persist, you must tell your doctor.

Side effects include nausea and vomiting, bloating, abdominal cramps or a bloated sensation, menstrual spotting or bleeding, increase in size of fibroids, vaginal thrush, nipple tenderness and breast discomfort, headache, swelling of the feet, weight gain, cramps in the legs, mild increase in blood pressure, dryness of the eyes that makes it difficult to wear contact lenses, irregular skin discoloration of the face (Chloasma) and gallstones.

There is always a potential to develop an allergic reaction to Prempak-C or to one of the ingredients in the formula. If you develop swollen lips, rash, difficulty breathing, dizziness or fainting, you should stop the medication and seek immediate medical attention.

Prempak-C Precautions

Prempak-C should be used with caution in the following women:

  • A family history of breast cancer
  • A history of fibroids, endometriosis or abnormal growth of the uterus
  • Personal or family history of blood clots or pulmonary embolism
  • Obesity
  • Presence of high blood pressure, varicose veins, heart failure of kidney disease
  • Smokers
  • Diabetics
  • With elevated levels of cholesterol or triglycerides
  • History of gallbladder disease
  • History of lupus
  • Have headaches or history of migraine
  • Have depression

Prempak-C should not be used by women with/who have/are:

  • Known, suspected or history of breast cancer
  • Known or suspected cancer stimulated by oestrogen
  • Endometrial hyperplasia
  • Vaginal bleeding with unknown cause
  • Blood disorders that could increase the risk of blood clots
  • Deep vein thrombosis or pulmonary embolism
  • Thrombophlebitis
  • Recently had a stroke caused by a blood clot
  • Recently had a heart attack
  • Angina pectoris
  • Active liver disease
  • Porphyrias
  • Pregnant or breastfeeding
  • Galactose intolerance, fructose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase insufficiency.

Pregnancy and Breastfeeding

Prempak-C should not be used in women who are pregnant or breastfeeding. If in case you think you could be pregnant while taking Prempak-C, stop treatment immediately.

Drug Interactions

Prempak-C can interact with other medications. Hence before you take the medication, you should tell the pharmacist or your doctor about all the medicines, herbs and supplements that you take. Sometimes small adjustments in dosage are required.

Following is a list of drugs that could reduce the blood level and effect of this medicine and can cause irregular menstrual bleeding or cause symptoms to return; aprepitant, bosentan, barbiturates, carbamazepine, cobicistat, crizotinib, dabrafenib, efavirenz, eslicarbazepine, fosaprepitant, fosphenytoin, modafinil, nevirapine, oxcarbazepine, phenobarbital, phenytoin, primidone, rifabutin, rifampicin, ritonavir, rufinamide, telaprevir, St John's wort, topiramate and vemurafenib.

Women with diabetes may need to alter their dose of insulin or antidiabetic tablets while taking Prempak-C. The drug also opposes the effect of blood pressure medicines therefore blood pressure should be regularly monitored while on HRT. Prempak-C may also oppose the effect of diuretics. It can decrease the amount of lamotrigine (antiepileptic) in the blood and increase the risk of seizures.

The blood levels of the following drugs may be increased because of Prempak-C thus increasing the risk of side effects; aminophylline, ropinirole, selegiline, theophylline and tizanidine.

Other Important Information

  • There is a risk that you may develop a blood clot in the legs after you take Prempak-C. The blood clot can break off and fly off to the lungs, brain or the heart. Women who have a history of blood clots, are obese, smoke or have a personal or family history of heart disease, should not take Prempak-C.
  • To avoid formation of blood clots, it is recommended that you maintain a healthy weight, remain physically active, do not smoke and wear compression stockings, if you travel long distance by car or plane, you must walk around every few hours and wear appropriate elastic garments.
  • To reduce the risk of blood clots after major surgery, your doctor may stop the hormonal therapy 4-6 weeks prior to the procedure.
  • If at anytime you develop calf pain, leg swelling, shortness of breath, dizziness, headache, fainting, yellow discolouration of skin, chest pain or coughing of blood, you must stop the pill and see your doctor as soon as possible.
  • Some women may develop changes in skin color around the face and upper body. These skin changes are benign and will disappear once Prempak-C is discontinued.
This is how we work
  • Select your medication

    Choose the medication you would like to order and select the appropriate dosage and quantity to proceed with your consultation.

  • Complete a private medical form

    Complete your medical consultation form which provides your online doctor with further information about your condition.

  • Doctor issues prescription

    Online doctor checks your medical form, a prescription is created and sent directly to our pharmacy who will then dispatch your medication.

  • Medication delivered the very next day

    Our registered UK pharmacy will complete a final dispatch check ensuring you receive the right treatment the following day.

  • Order the prescription for Prempak C only

    Our doctor will issue your prescription after a short online consultation. The Prescription will be sent to you and can be used in any pharmacy.

    Order your prescription now
  • Order your Prempak C to your door

    Our pharmacy will send your treatment right to your doorstep. this service includes doctor prescription and 24h express delivery.

    Order Prempak C now
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  • All-inclusive services:
  • Can be used in any pharmacy
  • FREE 24h delivery
  • Online Consultation
3h 10min for delivery tomorrow